Publications

28. N–H Bond Formation in a Manganese(V) Nitride Yields Ammonia by Light-Driven Proton-Coupled Electron Transfer. Wang, D.; Loose, F.; Chirik, P. J.; Knowles, R. R. J. Am. Chem. Soc. 2019, 141, 4795–4799. DOI: 10.1021/jacs.8b12957

27. Rate–Driving Force Relationships in the Multisite Proton-Coupled Electron Transfer Activation of Ketones. Qiu, G.; Knowles, R. R. J. Am. Chem. Soc. 2019, 141, 2721–2730. DOI: 10.1021/jacs.8b13451

26. A Redox Strategy for Light-Driven, Out-of-Equilibrium Isomerizations and Application to Catalytic C–C Bond Cleavage Reactions. Ota, E.; Wang, H.; Frye, N. L.; Knowles, R. R. J. Am. Chem. Soc. 2019, 141, 1457–1462. DOI: 10.1021/jacs.8b12552

25. Applications and Prospects for Triplet-Triplet Annihilation Photon Upconversion. Rauch, M. P.; Knowles, R. R. Chimia 2018, 72, 501–507DOI: 10.2533/chimia.2018.501

24. Enantioselective Synthesis of Pyrroloindolines via Non-Covalent Stabilization of Indole Radical Cations and Applications to the Synthesis of Alkaloid Natural Products. Gentry, E. C.; Rono, L. J.; Hale, M. E.; Matsuura, R.; Knowles, R. R. J. Am. Chem. Soc. 2018, 140, 3394–3402. DOI: 10.1021/jacs.7b13616

23. Intermolecular Anti-Markovnikov Hydroamination of Unactivated Alkenes with Sulfonamides Enabled by Proton-Coupled Electron Transfer. Zhu, Q.; Graff, D. E.; Knowles, R. R. J. Am. Chem. Soc2018, 140, 741–747. DOI: 10.1021/jacs.7b11144

22. Catalytic Intermolecular Hydroaminations of Unactivated Olefins with Secondary Alkyl Amines. Musacchio, A. J.; Lainhart, B. C.; Zhang, X.; Naguib, S. G.; Sherwood, T. C.; Knowles, R. R. Science 2017, 355, 727–730. DOI: 10.1126/science.aal3010

21. Catalytic Alkylation of Remote C–H Bonds Enabled by Proton-Coupled Electron Transfer. Choi, G. J.; Zhu, Q.; Miller, D. C.; Gu, C. J.; Knowles, R. R. Nature 2016, 539, 268–271. DOI: 10.1038/nature19811

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20. Catalytic Ring-Opening of Cyclic Alcohols Enabled by PCET Activation of Strong O-H Bonds. Yayla, H. G.; Wang, H.; Tarantino, K. T.; Orbe, H. S.; Knowles, R. R. J. Am. Chem. Soc. 2016, 138, 10794–10797. DOI: 10.1021/jacs.6b06517

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19. Synthetic Applications of Proton-Coupled Electron Transfer. Gentry, E. C.; Knowles, R. R. Acc. Chem. Res. 2016, 49, 1546–1556DOI: 10.1021/acs.accounts.6b00272

18. Catalytic Carbocation Generation Enabled by the Mesolytic Cleavage of Alkoxyamine Radical Cations. Zhu, Q.; Gentry, E. C.; Knowles, R. R. Angew. Chem., Int. Ed. 2016, 55, 9969–9973. DOI: 10.1002/anie.201604619

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17. Proton-Coupled Electron Transfer in Organic Synthesis: Fundamentals, Applications, and Opportunities. Miller, D. C.; Tarantino, K. T.; Knowles, R. R. Top. Curr. Chem. 2016, 374, 30. DOI: 10.1007/s41061-016-0030-6

16. Catalytic C-N Bond Forming Reactions Enabled by Proton-Coupled Electron Transfer Activation of Amide N-H Bonds. Nguyen, L. Q.; Knowles, R. R. ACS Catal. 2016, 6, 2894-2903. DOI: 10.1021/acscatal.6b00486

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15. Discovery and Mechanistic Study of a Photocatalytic Indoline Dehydrogenation for the Synthesis of Elbasvir. Yayla, H. G.; Peng, F.; Mangion, I. K.; McLaughlin, M. M.; Campeau, L.-C; Davies, I. W.; DiRocco, D. A.; Knowles, R. R. Chem. Sci. 2016, 7, 2066–2073. DOI: 10.1039/C5SC03350K

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14. Catalytic Olefin Hydroamidation Enabled by Proton-Coupled Electron Transfer. Miller, D. C.; Choi, G. J.; Orbe, H. S.; Knowles, R. R. J. Am. Chem. Soc. 2015, 137, 13492–13495. DOI: 10.1021/jacs.5b09671

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13. Reaching Your Full (Over)Potential: A Novel Approach to Electrocatalytic Oxygen Reduction. Knowles, R. R. ACS Cent. Sci. 2015, 1, 224–225. DOI: 10.1021/acscentsci.5b00257

12. Catalytic Alkene Carboaminations Enabled by Oxidative Proton-Coupled Electron Transfer. Choi, G. J.; Knowles, R. R. J. Am. Chem. Soc. 2015, 137, 9226–9229. DOI: 10.1021/jacs.5b05377

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 11. Bond-Weakening Catalysis: Conjugate Aminations Enabled by the Soft Homolysis of Strong N-H Bonds. Tarantino, K. T.; Miller, D. C.; Callon, T. A.; Knowles, R. R. J. Am. Chem. Soc. 2015, 137, 6440–6443. DOI: 10.1021/jacs.5b03428
 
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10. Proton-Coupled Electron Transfer in Organic Synthesis: Novel Homolytic Bond Activations and Catalytic Asymmetric Reactions with Free Radicals. Yayla, H. G.; Knowles, R. R. Synlett. 2014, 20, 2819–2826. DOI: 10.1055/s-0034-1379304

 

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9. Catalytic Olefin Hydroamination with Aminium Radical Cations: A Photoredox Method for Direct C-N Bond Formation. Musacchio, A. J.; Nguyen, L. Q.; Beard, G. H.; Knowles, R. R. J. Am. Chem. Soc. 2014, 136, 12217–12220. DOI: 10.1021/ja5056774

 

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8. Enantioselective Photoredox Catalysis Enabled by Proton-Coupled Electron Transfer: Development of an Asymmetric Aza-Pinacol Cyclization. Rono, L. J.; Yayla, H. G.; Wang, D. Y.; Armstrong, M. F.; Knowles, R. R. J. Am. Chem. Soc. 2013, 135, 17735–17738. DOI: 10.1021/ja4100595

 

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7. Catalytic Ketyl-Olefin Cyclizations Enabled by Proton-Coupled Electron Transfer. Tarantino, K. T.; Liu, P.; Knowles, R. R. J. Am. Chem. Soc. 2013, 135, 10022–10025. DOI: 10.1021/ja404342j

 

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 Pre-Princeton Publications

6. Total Synthesis of Diazonamide A. Knowles, R. R.; Carpenter, J. E.; Blakey, S. B.; Kayano, A.; Mangion, I. K.; Sinz, C. J.; MacMillan D. W. C. Chemical Science 2011, 2, 308–311.

5. Attractive Non-Covalent Interactions in Asymmetric Catalysis: Links Between Enzymes and Small-Molecule Catalysts. Knowles, R. R.; Jacobsen, E. N. Proc. Nat. Acad. Sci. USA 2010, 107, 20678–20685.

4. Concerning the Mechanism of the FeCl3-Cataylzed a-Oxyamination of Aldehydes. Evidence for a Non-SOMO Activation Pathway. Van Humbeck, J. F.; Simonovich, S. P.; Knowles, R. R.; MacMillan D. W. C. J. Am. Chem. Soc. 2010, 132, 10012–10014.

3. Enantioselective Thiourea-Catalyzed Cationic Polycyclizations. Knowles, R. R.; Lin, S.; Jacobsen, E. N. J. Am. Chem. Soc. 2010, 132, 5030–5032.

2. Modelling the Effects of Confinement on the Glass Transition Temperatures and Segmental Mobility. Kranbuehl, D.; Knowles, R.; Hossain, A.; Hurt, M. Journal of Physics: Condensed Matter 2003, 15, S1019–S1029.

1. Monte Carlo Simulations of the Effect of Confinement Geometry on the Lowering of the Glass Transition Temperature. Kranbuehl, D.; Knowles, R.; Hossain, A.; Gilchriest, A. Journal of Non-Crystalline Solids 2002, 307, 495–502.