Publications

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles” Aleem, S. U.*; Georghiou, G.*; Kleiner, R. E.*; Guja, K. E.; Craddock, B. P.; Lyczek, A.; Chan, A. I.; Garcia-Diaz, M.; Miller, W. T.; Liu, D. R.; Seeliger, M. A.; Cell Chem. Biol. (2016), http://dx.doi/10.1016/j.chembiol.2016.07.017

“Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends” Ti, S. C.; Pamula, M. C.; Howes, S. C.; Duellberg, C.; Cade, N. I.; Kleiner, R. E.; Forth, S.; Surrey, T.; Nogales, E.; Kapoor, T. M. Cell 4, 72-84 (2016).

“Chemical Proteomics Reveals a γH2AX-53BP1 Interaction in the DNA Damage Response” Kleiner, R. E.; Verma, P.; Molloy, K. R.; Chait, B. T.; Kapoor, T. M. Chem. Biol. 10, 807-814 (2015).

“Anti-Diabetic Activity of Insulin-Degrading Enzyme Inhibitors Mediated by Multiple Hormones” Maianti, J. P.; McFedries, A.; Foda, Z. H.; Kleiner, R. E.; Du, X.; Lessring, M.; Tang, W.; Charron, M. J.; Seeliger, M. A.; Saghatelian, A.; Liu, D. R.; Nature 511, 94-98 (2014).

“Bumping Up Kinase Activity with an ATP-Derived Neo-Substrate” Kleiner, R. E.; Kapoor, T. M. Cell 154, 716-718 (2013).

“Site-Specific Chemistry on the Microtubule Polymer” Kleiner, R. E.; Ti, S. C.; Kapoor, T. M. Am. Chem. Soc. 135, 12520-12523 (2013).

“Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles” Georghiou, G.*; Kleiner, R. E.*; Pulkoski-Gross, M.; Liu, D. R.; Seeliger, M. A. Chem. Biol. 8, 366-374 (2012).

“Small-Molecule Discovery from DNA-Encoded Chemical Libraries” Kleiner, R. E.*; Dumelin, C. E.*; Liu, D. R. Soc. Rev. 40, 5707-5717 (2011).

In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors” Kleiner, R. E.; Dumelin, C. E.; Tiu, G. C.; Sakurai, K.; Liu, D. R. Am. Chem. Soc. 132, 11779-11791 (2010).

“An In Vitro Translation, Selection and Amplification System for Peptide Nucleic Acid” Brudno, Y.; Birnbaum, M. E.; Kleiner, R. E.; Liu, D. R. Chem. Biol. 6, 148-155 (2010).

“DNA-Templated Polymerization of Side-Chain-Functionalized Peptide Nucleic Acid Aldehydes” Kleiner, R. E.; Brudno, Y.; Birnbaum, M. E.; Liu, D. R. Am. Chem. Soc. 130, 4646-4659 (2008).

“An Intein-Based Genetic Selection Enables Construction of a High-Quality Library of Binary Patterned De Novo Sequences” Bradley, L. H.; Kleiner, R. E.; Wang, A. F.; Hecht, M. H.; Wood, D.W. Protein Eng. Des. Sel. 18, 201-207 (2005).