Assistant Professor, Principal Investigator
Lab phone: 609-258-8767
Princeton University, A.B. in Chemistry
Harvard University, Ph.D. in Chemistry
Ralph Kleiner was born in Syracuse, NY and attended Princeton University, where he received an A.B. in Chemistry and performed research on the de novo design of 4-helix bundle proteins in the laboratory of Michael Hecht. He then completed his Ph. D. in Chemistry at Harvard University under the direction of David Liu, where he used DNA-templated chemistry to identify novel macrocyclic inhibitors of Src kinase and Insulin-Degrading Enyzme (IDE). He went on to conduct his postdoctoral studies as a Damon Runyon Postdoctoral Fellow with Tarun Kapoor at The Rockefeller University. His postdoctoral work used chemical proteomics to study phosphorylation-dependent protein-protein interactions in the DNA damage response. In September 2016, Ralph began his appointment as an Assistant Professor in the Department of Chemistry at Princeton University. His research lies on the interface of chemistry and biology, focusing on the development and application of novel chemical approaches to investigate challenging problems in cellular biology. He is particularly interested in understanding how chemical modifications occurring on nucleic acids regulate the function of these macromolecules.
He is a recipient of a Damon Runyon Postdoctoral Fellowship, a Revson Foundation Senior Fellowship in Biomedical Science, the Damon Runyon Dale F. Frey Award for Breakthrough Scientists, the Sidney Kimmel Foundation Scholar Award, the Alfred P. Sloan Foundation Research Fellowship, and the National Science Foundation CAREER Award.