The Groves Lab

“Oxidative aliphatic C-H fluorination with fluoride ion catalyzed by a manganese porphyrin”

“A highly reactive p450 model compound I”; “Dissection of the mechanism of manganese porphyrin-catalyzed chlorine dioxide generation”

“Detection and Kinetic Characterization of a Highly Reactive Heme-Thiolate Peroxygenase Compound I”; “Parallel and competitive pathways for substrate desaturation, hydroxylation, and radical rearrangement by the non-heme diiron hydroxylase AlkB”

“Single vesicle observations of the cardiolipin-cytochrome C interaction: induction of membrane morphology changes”; “Peroxynitrite Mediates Active Site Tyrosine Nitration in Manganese Superoxide Dismutase. Evidence of a Role for the Carbonate Radical Anion”

The major thrust of our research program is at the interface of organic, inorganic, and biological chemistry. Many biochemical transformations, as well as important synthetic and industrial processes, are catalyzed by metals. Enjoy exploring the wide scope of our research in the bioinorganic and bioinspired catalysis fields!