Asymmetric Alkene Hydrogenation
The second class of compounds utilizes bidentate phosphine ligands and enables hydrogenation of functionalized alkenes such as those more typically found in drug-like molecules (Science 2013, 342, 1076.). Mechanistic studies support a more precious metal-like two-electron redox couple.
Selected Publications
Cobalt-Catalyzed Enantioselective Hydrogenation of Minimally Functionalized Alkenes: Isotopic Labeling Provides Insight into the Origin of Stereoselectivity and Alkene Insertion Preferences
Max R. Friedfeld, Michael Shevlin, Grant W. Margulieux, Louis-Charles Campeau, and Paul J. Chirik
J. Am. Chem. Soc. 2016, 138, 3314-3324.
Iron- and Cobalt-Catalyzed Alkene Hydrogenation: Catalysis with Both Redox-Active and Strong Field Ligands
Paul J. Chirik
Acc. Chem. Res. 2015, 48, 1687–1695.
Cobalt Precursors for High-Throughput Discovery of Base Metal Asymmetric Alkene Hydrogenation Catalysts
Max R. Friedfeld, Michael Shevlin, Jordan M. Hoyt, Shane W. Krska, Matthew T. Tudge, Paul J. Chirik
Science 2013, 342, 1076-1080.
Enantiopure C1-Symmetric Bis(imino)pyridine Cobalt Complexes for Asymmetric Alkene Hydrogenation
Sebastien Monfette, Zoë R. Turner, Scott P. Semproni, and Paul J. Chirik
J. Am. Chem. Soc. 2012, 134, 4561-4564.